- October 23, 2000 - Bishop John H. Ricard of the Diocese of Pensacola-Tallahassee says the first Mass in the restored Mission San Luis church in more than 300 years.
- May 1, 2006 - Mission San Luis receives the Preserve America Presidential Award.
- December 11, 2006 - Groundbreaking for the Castillo de San Luis.
- March 2007 - The Castillo de San Luis opens to visitors.
- May 3, 2008 - Groundbreaking for new Mission San Luis Visitor Center.
- December 13, 2009 - Grand opening of the new Mission San Luis Visitor Center.